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KMID : 0363219700080010003
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Korean Journal of Dermatology
1970 Volume.8 No. 1 p.3 ~ p.9
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Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats
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金源錫/Kim, Won Suk
林壽德/金洪植/Lim, Soo Duk/Kim, Hong Sik
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Abstract
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Several immunosuppressive agents were used to prolong the survival of full-thicknes skin homografts in albino rats. The grafts were squares in size of 2.Ocm. The results were as follows.
1. The mean survival time of skin homografts in control group was 6.0 days.
2. Total body X-irradiation (500r) to the recipients 24 hours before grafting resulted in prolongation of survival of the grafts. (Mean, 12.5 days)
3. Administration of Imuran(azathioprine) to the recipients in a does of 5mg/kg/day for 7 days before grafting resulted in prolongation of survival of the grafts. (Mean, 9.6 days)
4. Splenectomized homografted rats showed no prolongation of survival of the grafts. (Mean, 6.1days)
5. Administration of prednisolone to the recipients in a does of 2mg/kg/day for 7 days before grafting resulted in no prolongation of survival of the grafts. (Mean, 6.3 days)
6. Above results were discussed and compared with those of others.
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